Proteins Lipids Organelles
Ubiquitination Song
Created by students in Spring 2018
You’ve got damaged proteins
A target on their back.
A protein called ubiquitin
Preparin’ for attack.
Ubiquitination
What a cool technique
I’m gonna share a few things, needed
For degradation to proceed
E1, binds ubiquitin
Brings it to E2
E3 and E4
Damaged proteins no more
Proteolysis
A chain begins, on lysine residues
And now that the u- chain grew
A signal is sent, proteasome
“Rid damage and make new.”
Now where can this happen
It can't be anywhere,
We as humans are eukaryotes
It needs nucleiiiiiiii
E1, binds ubiquitin
Brings it to E2
E3 and E4
Damaged proteins no more
Proteolysis
A chain begins, on lysine residues
And now that the u- chain grew
A signal is sent, proteasome
“Rid the damage and make new.”
I never knew our bodies helped us all the ways that they do.
Ubiquitin combative
We need this process to live.
Damaged no more
Proteolysis
A chain begins, on lysine residues
And now that the u- chain grew
A signal is sent, proteasome
Damaged proteins no more
Proteolysis
A chain begins, on lysine residues
And now that the u- chain grew
A signal is sent, to the proteasome
“Rid damage and make new.”
Rid damage and make new
“Rid damage and make new.”