Proteins Lipids Organelles

You’ve got damaged proteins

A target on their back.

A protein called ubiquitin

Preparin’ for attack.

Ubiquitination

What a cool technique

I’m gonna share a few things, needed

For degradation to proceed

E1, binds ubiquitin

Brings it to E2

E3 and E4

Damaged proteins no more  

Proteolysis

A chain begins, on lysine residues

And now that the u- chain grew

A signal is sent, proteasome

“Rid damage and make new.”  

Now where can this happen

It can't be anywhere,

We as humans are eukaryotes

It needs nucleiiiiiiii

E1, binds ubiquitin

Brings it to E2

E3 and E4

Damaged proteins no more  

Proteolysis

A chain begins, on lysine residues

And now that the u- chain grew

A signal is sent, proteasome

“Rid the damage and make new.”   

I never knew our bodies helped us all the ways that they do.

Ubiquitin combative  

We need this process to live.

Damaged no more  

Proteolysis

A chain begins, on lysine residues

And now that the u- chain grew

A signal is sent, proteasome

Damaged proteins no more  

Proteolysis

A chain begins, on lysine residues

And now that the u- chain grew

A signal is sent, to the proteasome

“Rid damage and make new.”  

Rid damage and make new

“Rid damage and make new.”