Membrane Transport Song - to the tune of Bruno Mars "That's What I Like"
Created by Aine McGovern and classmates in Fall 2017
I got a lipid bilayer
Its permeable but selective
Simple diffusion, no confusion
Small nonpolar just flows through
02 and steroid hormones
Have no problem passing through
But polar molecules
Need some help to diffuse
That’s where membrane proteins
Come in to facilitate transport
Ions with a charge can’t make it
Through the hydrophobic interior
There are channels and transporters
Both are highly selective
Open in response to ligand,
Voltage or mechanical change
(CHORUS)
Come to my membrane
Yeah we gotta transport
Not just anything
Can go through my bilayer
Can you just diffuse it
No you got a charge
I gotta facilitate you
We got that TRANSPORT
Can be passive or active
Lucky for ions we got channels (we got channels)
Lucky for ions we got pumps (we got pumps)
Passive goes down your gradient
Based on concentration and voltage
A ligand binds onto a channel (onto a channel)
It opens up and passes through (and passes through)
(VERSE 2)
I’m talking ‘bout membrane potential
We got charges on both sides
There’s also ion concentration
Formed by protein transportation
Add it all to
Electrochemical gradient for that ion
This will provide stored energy for the cell
Low sodium inside the cell
But high potassium
It’s just more negative in here
This helps the cell function
Is it in (is it in)?
Is it out (is it out)?
What direction is the gradient?
Then that’s where the ion will flow
(CHORUS)
Come to my membrane
Yeah we gotta transport
Not just anything
Can go through my bilayer
Can you just diffuse it
No you got a charge
I gotta facilitate you
We got that TRANSPORT
Can be passive or active
Lucky for ions we got channels (we got channels)
Lucky for ions we got pumps (we got pumps)
Active goes against your gradient
Energy required, where’s the ATP?
Or there’s a coupled pump you see (oh you see)
It sends two molecules using built up energy
(BRIDGE)
But then there’s just this one pump
It creates the most important
Electrochemical gradient
Sodium Potassium ATPase
Driven by ATP
3 Sodiums out
2 Potassiums in
That’s how the gradient forms
Coupled pumps,
Symports and antiports
Use this gradient to move their molecules
(CHORUS)
We got that TRANSPORT
Can be passive or active
Lucky for ions we got channels (we got channels)
Lucky for ions we got pumps (we got pumps)
After this gradient forms
Gotta get back to the resting potential
Potassium leak channels open up (they open up)
They balance membrane gradients (they balance them)