Cell Division

Cell Division Song - to the tune of Kelly Clarkson's Breakaway

Created by Dorothy Peng, Rachel Moon, Emily Zhao in Spring 2017

Started with mitogens

Activated cyclin

Dephosphorylates Cdk

Inhibitor releases

And then cyclin binds

Cdk (is active)

Cdc6 loads up

helicase on DNA

Cdk phosphorylates Cdc6

Helicase also

So DNA is ready

And the strands will break away

All DNA are now replicated

And DNA damage is now all repaired

Cdc25

Accumulates

Dephosphorylates

M-Cdk

And M-Cdk then goes back around

And phosphorylates Cdc25 now

Positive

Feedback

Activates

MAPs and condensins

Double check the spindle

Chromosomal tension

Signals APC to cleave securin

Separase is active

And degrades cohesins - from sister chromatids

They break away

Cell cycle checkpoints

Are simple enough

G1-S phase can be super fun

Cells take a risk

Take a chance

Make a change

To break away

G2 to M won’t come with ease

Metaphase and anaphase ain’t such a breeze

But Cells take a risk

Take a chance

Make a change

And breakaway, breakaway, breakaway