Cell Division
"Ras On" Song - to the tune of "Masks Off"
Created by Maddie Heard, Juliet Blasetti, Tristan Martin, Loryn Bucci, Jack McNamara in Spring 2017
RTK
Pathway RTK
RTK
Pathway RTK
Ligand binds
Finna dimerize
MAPKs activate
Cell growth upregulate
Ras On,
Screw it, Ras off
Ras On,
Screw it, Ras off
RTK
Pathway RTK
MAPKs activate
Cell growth upregulate
Ras-Gef,
Causin’ GTP exchange
From inactivity
To a signalin’ cascade
Protein Ras
Gives up GDP
MAPs phosphorylatin’
Starts kinase activity
Other side
PI3 kinase
Indirectly
Turns on Akt
Also called
Protein Kinase B
Tor turns on
Protein synthesis
Cell growth
Cytoskeletal change
Division
Differentiation
Ras-Oncogene on
That’s a liability
Hit the gas
You gon’ need some medicine
Oncogenes on
Tumor suppressors off
Oncogenes on
Tumor suppressors off
Neoplasia
Finna go malignant
Metastasize
Invading other tissues
Goin’ wild
Division goin’ wild
Goin’ wild
Division goin’ wild
RTK
Pathway RTK
Apoptose?
Neva’ apoptose